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DTF-LCPG # 191 - Question Sheet
by claudio barros June 15, 2022

June 15, 2022

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DTF-LCPG #190 - Answer Sheet
by claudio barros June 15, 2022

June 15, 2022

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Associate Director/Director, Preclinical Safety Assessment, Tango, Cambridge, Boston MA Therapeutics
by Bruce Williams June 9, 2022

June 9, 2022

*Company Overview* Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. Tango’s labs and offices are currently located in Cambridge. We will be relocating to a new space at 201 Brookline Avenue, in the Fenway area of Boston, in Q3 2022. *Job Summary:* Reporting to the Head of Pharmaceutical Sciences, this individual will provide the leadership, functional expertise, and sense of urgency to develop and execute non-clinical drug development strategies. This position has functional responsibilities for Preclinical Safety Assessment. *Job Responsibilities:* · Works closely with Discovery Chemistry, Research Pharmacology, Drug Metabolism & Pharmacokinetics, Clinical Pharmacology, Clinical Development and Regulatory Affairs to implement discovery and development toxicology strategies that enable the progression of optimized drug candidates. · Responsible for pre-clinical safety assessments: safety pharmacology, genetic toxicology, general toxicology, reproductive toxicology, and toxicokinetics. · Lead the development of early hypothesis-driven investigation into mechanisms of toxicity. · Proactively manage potential safety liabilities. · Provide strategic and operational leadership for nonclinical development programs. · Plan and execute nonclinical safety studies (investigative, non-GLP and GLP). · Provide strategic guidance to project teams and senior management. · Develop study protocols: review, revise, and issue regulatory reports. · Prepare regulatory documents including briefing books, investigational new drug applications (INDs), Investigator Brochures (IBs), New Drug Applications (NDAs), and Marketing Authorization Applications (MAAs). · May act as the company toxicology representative with health authorities. · Work with program leadership to meet timelines and objectives. · Responsible for developing and maintaining CRO and consultant relationships. · Perform due diligence reviews on potential in-licensing candidates. · Develop target safety reviews with risk mitigation plans for early drug discovery teams. · Prepare relevant Standard Operating Procedures (SOPs) pertaining to pre-clinical safety. *Skills & Qualifications:* · DVM or Ph.D. in an area relevant to pre-clinical safety assessment is required · Diplomat of the American Board of Toxicology (DABT) or American College of Veterinary Pathology (ACVP) board certification is highly desired · Minimum of 8 years of progressive post-graduate work experience is required · To be considered for Director level you must have a · Experience in biotechnology or pharmaceutical industry is preferred · At least 2 years of experience in the oncology therapeutic area is required · Previous experience with successful regulatory submissions (INDs and/or NDAs) as lead toxicologist is highly desired · Experience managing CRO relationships is a plus · In-depth understanding of small molecule drug discovery and development is preferred · Sound theoretical and experimental background in toxicology and pharmacology · Current knowledge of Good Laboratory Practices (GLP) · Working knowledge of US and international regulatory requirements for the design and conduct of nonclinical safety studies · Experience interacting with the FDA and ex-US regulatory authorities is preferred · Ability to influence positively including in situations without direct authority · Excellent verbal and written communication and skills · Ability to work independently and collaboratively, in a matrix team environment consisting of internal and external team members · Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines · Excellent planning, organization and time management skills including the ability to support, prioritize, and multi-task *We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.To apply, visit: * https://boards.greenhouse.io/tangotherapeutics/jobs/5166064003#app -- Bruce Williams Chief Financial Officer Davis-Thompson Foundation 301 467-4024 bruce.williams(a)davisthompsonfoundation.org www.davisthompsonfoundation.org

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Residency/Postdoctoral Scholar in Veterinary Anatomic Pathology
by Bruce Williams June 9, 2022

June 9, 2022

Residency/Postdoctoral Scholar in Veterinary Anatomic Pathology University of Kentucky-Lincoln Memorial University-College of Veterinary Medicine Applications are being accepted for a 3-year training position in veterinary anatomic pathology formed through a cooperative agreement between the University of Kentucky Veterinary Diagnostic Laboratory (UKVDL) and Lincoln Memorial University-College of Veterinary Medicine (LMU-CVM). Training will be based in Lexington, Kentucky with additional educational opportunities at LMU-CVM in Harrogate, Tennessee. The residency training program will prepare the trainee for a career in veterinary anatomic pathology through exposure to a high diagnostic case load, educational rounds, and seminars. Residents who successfully complete the program will be qualified to take the American College of Veterinary Pathology (ACVP) certifying examination. Pathology residents will develop skills in gross pathology and histopathology by participating in a busy diagnostic laboratory service, weekly pathology rounds, and by cross-training at other veterinary institutions. Residents will participate in the in-house instruction of senior veterinary students from LMU-CVM. The opportunity to provide lectures for 1st to 3rd year LMU-CVM veterinary students is available, if desired. Residents are expected to actively participate in weekly seminars in gross, microscopic, and clinical pathology and other specialty pathology rounds. The resident will be supported by six ACVP diplomates certified in anatomic pathology, two residency trained pathologists, and other faculty from the LMU-CVM and University of Kentucky, including the Gluck Equine Research Center. The UKVDL caseload includes a wide variety of domestic animals with a large animal emphasis. On average, the UKVDL performs approximately 3,000 necropsies and 2,500 surgical biopsies each year. Applicants are required to have a DVM or equivalent degree by the start date (July 1, 2023) and possess excellent communication skills. Candidate selection will be based on the applicant’s academic record, experience, recommendations, and evidence of a commitment to a career in veterinary pathology. Applicants who wish to subsequently pursue a MS or PhD degree should address this in their application materials; a separate application to the graduate school is required. The successful applicant will be appointed as a University of Kentucky Postdoctoral Scholar. The position will be annually renewable, with reappointment dependent on satisfactory performance and available funding. Starting salary is $47,500 with benefits. A complete list of Postdoctoral Scholar benefits can be found at https://www.uky.edu/postdoc/benefits <https://www.uky.edu/postdoc/benefits?fbclid=IwAR2Iq-IZThvgwg-vp4H2AISIddUGq…> . The College of Agriculture, Food and Environment (CAFE) is fulfilling the land-grant promise of educational excellence, civic leadership, transformational research, and shared knowledge serving the common good. We serve the people of the Commonwealth of Kentucky and across the world through education, outreach, service, and research by finding solutions to improve lives today and create a sustainable future. We integrate teaching, research, and extension in our work. We recruit, retain, and train graduate students who are competent, responsible, and workforce ready. For more than 130 years, CAFE has provided research results to the community. From traditional labs and research farms to high-tech diagnostic and research centers, we offer science-based, practical solutions that affect the everyday lives of Kentuckians and people around the world. Our Cooperative Extension programs are engaged in Kentucky’s 120 counties, identifying and addressing needs not only in agriculture and natural resources, but also 4-H and youth development, family and consumer sciences, as well as community & economic development. We create a welcoming and inclusive environment that allows our faculty, staff, and students to reach their highest potential. We recognize people with diverse backgrounds and experiences are essential to decision making, problem solving, and innovation each and every day. The University of Kentucky is a university with approximately 23,000 undergraduate and 7,000 graduate students. UK is Kentucky’s flagship university and a land grant institution. We have a university commitment to improve the lives of Kentuckians and beyond and that is why environmental stewardship and sustainability are core parts of our institution’s legacy. We are recognized as a Tree Campus USA by the Arbor Day Foundation, a Gold level Bicycle Friendly University by The League of American Bicyclists, and are recognized as a STARS (Sustainability Tracking, Assessment & Rating System) Silver Rating by the Association for the Advancement of Sustainability in Higher Education. The university is geographically near downtown Lexington, which offers the vibrancy of an urban location while being in close proximity to working landscapes and recognized wilderness areas. It is a thriving community of 300,000+ with a strong commitment to quality of life, education, and the arts. Lexington is in the Bluegrass Region, an internationally acclaimed cultural landscape and agricultural region. The University of Kentucky and the College of Agriculture, Food and Environment (CAFE) are committed to creating a diverse, equitable, and inclusive environment of mutual respect where all members of our community are able to fully engage, belong, and succeed. We support and welcome applicants of all identities such as but not limited to race, ethnicity, gender identity and expression, perspectives, beliefs, sexual orientation, national origin, religious belief, or age, and all qualified candidates are encouraged to apply. The University of Kentucky is an equal opportunity university. We encourage applications from women, minorities, and all interested and qualified people. The EEO Coordinator is Tim West, S-105 Agricultural Science North, University of Kentucky, Lexington, KY 40546-0091. How to Apply / Contact Interested applicants should email their application materials to melissa.swan(a)uky.edu by August 10th. However, the position will remain open until a qualified candidate has been identified. Application materials should include: 1) a one-page statement of career goals and interests, 2) a current curriculum vitae—including completed education, pertinent employment history, and relevant experience, 3) college transcripts, and 4) three letters of recommendation from individuals knowledgeable of the applicant’s academic performance, clinical skills, and pathology experience. -- Bruce Williams Chief Financial Officer Davis-Thompson Foundation 301 467-4024 bruce.williams(a)davisthompsonfoundation.org www.davisthompsonfoundation.org

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Veterinary Pathologist - California National Primate Research Center
by Bruce Williams June 7, 2022

June 7, 2022

We have an opportunity for a pathologist to join to the Anatomic Pathology team at The California National Primate Research Center. This position offers a level of mentorship and support that is perfect for either early career or new pathologists who will finish their residency training programs this year. No previous primate experience is needed, but an interest in learning non-human primate pathology and working in a research environment is a must. The position offers a wide variety of experience involving teaching, diagnostic pathology as well as research pathology. We work closely with the UC Davis School of Veterinary Medicine and the Comparative Pathology Lab, both of which are just down the street. ACVP boards or board eligibility is required but a PhD is not necessary. If this opportunity sparks your interest please don’t hesitate to reach out to Rachel Reader at rreader(a)ucdavis.edu. We welcome informal conversations with potential candidates. To apply please use the following link: https://careerspub.universityofcalifornia.edu/psp/ucdavis/EMPLOYEE/HRMS/c/H… Dr J. Rachel Reader BVSc (Hons) PhD Diplomate ACVP Manager and Senior Veterinary Pathologist CNPRC Health Science Clinical Professor Department of Pathology Microbiology and Immunology: SVM U.C.Davis Office phone (530) 752 3482 -- Bruce Williams Chief Financial Officer Davis-Thompson Foundation 301 467-4024 bruce.williams(a)davisthompsonfoundation.org www.davisthompsonfoundation.org

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Senior Veterinary Pathologist Opening - Medtronic, Minneapolis MN
by Bruce Williams June 5, 2022

June 5, 2022

As a veterinary pathologist at Medtronic Physiological Research Laboratories (PRL), you will plan, deliver, and interpret pathology data from exploratory or regulatory preclinical studies and work with all Medtronic operational units. Foremost, this pathologist will conduct analyses of implantable biomaterials/devices by applying gross and histological pathology expertise focused on the host-device interactions and their biocompatibility or treatment outcome. Finally, this pathologist will deliver scientific reports and offer comprehensive pathology knowledge. *RESPONSIBILITIES* · Collaborates with study sponsors across all Medtronic operational units as well as PRL departments in the design, refinement, and execution of preclinical research efforts. · Responsible for the pathology sections of preclinical studies, from researching the most appropriate model or methods, to budgeting, protocol writing, analysis, reporting and to possible regulatory rebuttal. · Exercises independent judgment in establishing evaluation criteria and methods for the acquisition and optimization of pathologic data in alignment with best-practices and with outlines in national or international regulatory agencies. · Timely completion of pathology reports after consultation with other involved scientists. *QUALIFICATIONS* To be considered for this position, the following basic qualifications must be evident on your resume: *Education Required -* Doctor of Veterinary Medicine, DVM from an accredited national or international University. Completed or nearly completed a Residency in Veterinary Anatomic Pathology (ACVP or ESVP board eligible). *Years of Experience - *Minimum of 3 years of anatomical veterinary pathology (gross and microscopic) in an Institution with a diverse case load across several animal species and a variety of diagnostic needs. *Specialized Knowledge or Skills Required* · Proficient in the whole pathology process. · Advanced and highly effective in written English. · High degree of self-motivation, independence, and time management skills. · Eagerly sharing knowledge and humble display of diagnostic vulnerability. · Professional verbal communication skills. · Computer skills: working knowledge of contemporary programs and apps. · Ability to handle stress and conflict constructively. *JOB POSTING* Full job posting available @ jobs.medtronic.com ID: 220006FN Contact Ian Courtney for further details if needed at ian.courtney(a)medtronic.com or 763-514-6888 *CAREERS THAT CHANGE LIVES* *Engineers and Scientists create our market-leading portfolio of innovations. Join us to make a lasting impact. Help bring the next generation of life-changing medical technology to patients worldwide. * *Together, we can change healthcare worldwide. At Medtronic, we push the limits of what technology can do to help alleviate pain, restore health, and extend life. We challenge ourselves and each other to make tomorrow better than yesterday. It is what makes this an exciting and rewarding place to be.* *Join us to make a lasting impact. Help bring the next generation of life-changing medical technology to patients worldwide.* -- Bruce Williams Chief Financial Officer Davis-Thompson Foundation 301 467-4024 bruce.williams(a)davisthompsonfoundation.org www.davisthompsonfoundation.org

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Veterinarian (Prosector) - Oregon National Primate Research Center
by Bruce Williams June 4, 2022

June 4, 2022

The Oregon National Primate Research Center (ONPRC) is located 12 miles west of the OHSU main campus, and sits on 162 acres of land featuring forested areas, research and administration buildings, indoor and outdoor animal housing, a pond, and 2-mile perimeter walking path. Our mission is to improve human health and the quality of life through the support of nonhuman primate research programs that advance our knowledge of the causes, preventions, treatments, and cures of debilitating diseases. This is a full time one-year position for a veterinarian (prosector) within the Pathology Services Unit (PSU) of the Animal Resources & Research Support (ARRS) which provides advanced comparative pathology services to ONPRC core scientists, veterinarians, OHSU affiliates, and external investigators. This position serves the ONPRC mission through conduct of research-directed post mortem examinations, provision of tissues through the Tissue Distribution Program and diagnostic support of the NHP colony. The veterinary prosector performs post mortem examinations, interprets clinical histories, clinical pathology data, microbiology, and other ancillary test results, and prepares written reports of findings. Additional duties include resource development for the unit through digital slide scanning, data collation and interpretation, preparation of materials for manuscript preparation and image database inclusion, and support of the Tissue Distribution Program through record review, tissue dissections, and coordination of tissue collection for investigators. The veterinary prosector must communicate clearly with end users – research staff and veterinarians. Extensive on the job training will be provided for recognition of nonhuman primate (NHP) specific diseases, specialized techniques, including perfusion, and specialized tissue handling for tissue distribution. This position provides abundant opportunity and resources for self-directed learning and potential inclusion in publications. Required Qualifications - D.V.M./V.M.D. degree from a veterinary school accredited by the American Veterinary Medical Association - Pathology experience in DVM curriculum - Ability to communicate effectively in English, in written and oral formats - Strong organizational skills - Strong interpersonal skills - Work is performed in a laboratory setting, with potential risk of exposure to hazardous chemicals, human and monkey tissue potentially containing agents infectious to humans including Macacine herpesvirus 1, other biohazardous agents, and dry ice - Some work conducted at Animal Biosafety Level 3 - Ability to carry and lift up to 50 lbs. - Adequate manual dexterity and visual acuity to perform tissue dissections, gross and microscopic evaluations, and operate a microscope - Ability to wear required personal protective equipment including powered air purifying respirator (PAPR) - Able to perform the essential functions of the position with or without accommodation Preferred Qualifications - Additional experience such as pathology-specific externships - Six months or more post- DVM clinical experience - Six months or more of research experience - Ability to organize data, prepare materials for scientific manuscripts Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo(a)ohsu.edu. As an organization devoted to the health and well-being of people in Oregon and beyond, OHSU requires its employees to be fully vaccinated against COVID-19. Please submit cover letter, CV/resume and references when applying . Apply at https://externalcareers-ohsu.icims.com/jobs/17289/veterinary-prosector/job?… -- Bruce Williams Chief Financial Officer Davis-Thompson Foundation 301 467-4024 bruce.williams(a)davisthompsonfoundation.org www.davisthompsonfoundation.org

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July call for Davis-Thompson Foundation cover art
by Katherine D. Watson June 3, 2022

June 3, 2022

Cool off for summer by submitting your awesome images to be featured on the cover of the Davis-Thompson Foundation Newsletter! Submission information (see attached for detailed information): * Submission deadline: June 15th, 2022 * Send your image by e-mail to: * Dr. Katherine Watson: images(a)davisthompsonfoundation.org<mailto:images@davisthompsonfoundation.org> Cheers, Kate Watson, DVM PhD DACVP California Animal Health and Food Safety Laboratory Assistant Professor of Anatomic Pathology "Mortui vivos docent" <http://www.vetmed.ucdavis.edu/research/grad_education/vstp/index.cfm> Publication List<http://scholar.google.com/citations?user=cGQfYQoAAAAJ&hl=en> "I know quite certainly that I myself have no special talent. Curiosity, obsession and dogged endurance, combined with self-criticism, have brought me to my ideas." - Albert Einstein

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June Newsletter Davis-Thompson Foundation
by Francisco A. Uzal June 1, 2022

June 1, 2022

Dear colleagues Welcome to the June issue of the Davis-Thompson Foundation Newsletter, prepared by our fantastic Managing Editors Jeann Leal and Javier Asin. As usual, this issue comes full of information on our training activities around the world, including an increasing number of face to face seminars and workshops, which are slowly coming back to life after more than two years of almost exclusively virtual teaching. While we will continue offering some virtual training in the future (e.g. our “4 big courses” are fully virtual this year), we hope to keep increasing the number of in person courses as the COVID pandemic allows. Finally, please remember that: Today is the last day to register for the Descriptive Pathology Course (see details in the newsletter and in our website) Looking forward to seeing you in one or more of our training activities soon. Enjoy Francisco Uzal, DVM, MSc, PhD, Dipl. ACVP Chief Executive Officer Davis-Thompson Foundation Ph: 951 751 0027 E-mail: fauzal(a)ucdavis.edu<mailto:fauzal@ucdavis.edu> www.davisthompsonfoundation.org<https://www.davisthompsonfoundation.org/> [https://drive.google.com/uc?id=1oticUQZYjDPU-1vMA4wHKvLb2SScHV-J]

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DTF-LCPG # 190 - Question Sheet
by claudio barros June 1, 2022

June 1, 2022

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