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Call for papers on the pathology of humanized mouse models for an upcoming special edition of Veterinary Pathology
by Bruce Williams Sept. 2, 2024

Sept. 2, 2024

*Call for papers on the pathology of humanized mouse models* ** Over the last decade, the use of humanized mouse models engrafted with a variety of tissues and cells of human origin has become one of the experimental paradigms most frequently used in translational research. This has been possible thanks to the establishment of genetically engineered mice with severely impaired innate and adaptive immune systems, such as NSG or NOG mice, offering a highly permissive recipient environment for the functional integration of the xenotransplanted human components. Humanized mouse models have been successfully employed for diverse experimental applications, including patient-derived tumor xenograft (PDX) models, preclinical testing of cellular immunotherapies, and other non-neoplastic human diseases. However, a series of unintended post-transplant disorders have been characterized in recent years. These disorders are clinically relevant for mouse recipients, limiting their usage, especially for longer-term studies, and represent potential experimental confounders for interpreting preclinical data. Given the increasing importance of humanized mice, raising awareness of inherent limitations and unintended consequences of human chimerism is paramount to better understanding the preclinical relevance and translational potential of these models. To this aim, veterinary and comparative pathologists working with immunocompromised and humanized mouse models are uniquely positioned to help define the spectrum of experimentally induced and spontaneous (infectious and noninfectious) conditions affecting these chimeric animals through intentional and pathological characterization. Therefore, the journal *Veterinary Pathology* is issuing a call for papers for a special issue on "The Pathology of Humanized Mouse Models" and encouraging submission of primary research papers. *Veterinary Pathology <https://uze9evdbb.cc.rs6.net/tn.jsp?f=001Lxf0z2n2WJxqiFGETVwGGTEeUeUSAFkf0P…>* is the journal of the American College of Veterinary Pathologists, the European College of Veterinary Pathologists, and the Japanese College of Veterinary Pathologists. Research Papers for the special issue should focus on one or more of the following aspects: (1) Description of naturally occurring diseases (infectious and noninfectious) of immunocompromised mouse strains used for humanization. (2) Description of post-transplant experimentally induced conditions affecting immunocompromised mice used for humanization. (3) Assessment of the pathology endpoints in preclinical studies using mouse recipients for human cellular immunotherapies. (4) Approaches to study the nature and extent of chimerism in humanized mice. (5) Beyond humans, description of chimeric mouse models xenotransplanted with tissues or cells from non-human species. (6) Beyond mice, description of humanized models employing non-nurine immunocompromised animals as recipients. Interested authors are advised to send a short abstract summary or prospectus to the guest editors, *Dr. Charles Assenmacher <chasse(a)vet.upenn.edu>*, *Dr. Enrico Radaelli <enrada(a)vet.upenn.edu>*, and *Dr. Pedro Ruivo <prruivo(a)ucdavis.edu>* before submitting a manuscript. Please submit abstracts for consideration by *Monday, September 30, 2024. *Upon review, corresponding authors will be contacted via e-mail regarding the status of their proposal(s) and the next steps. *Veterinary Pathology *publishes basic and applies research involving domestic, laboratory, and zoo animals, wildlife, poultry, and other animals. The scope of the journal includes novel descriptions of pathologic changes, clinical pathology and clinical-pathologic correlations for natural and experimental diseases of animals, investigations of the molecular and cellular mechanisms of disease (general pathology) and other aspects of pathogenesis, descriptions and use of animal models of human disease, and studies of pharmaceutical and environmental hazards. Manuscripts considered for publication must: 1. have significant importance to animal and/or human health, 2. include new knowledge supported by valid data, 3. address disease mechanisms (pathogenesis, pathophysiology) or pathologic findings in important new or emerging diseases or clinicpathologic correlations, 4. AND be of sufficiently broad interest to be of substantial value to veterinary pathologists. For more info, please contact: *Pedro R. Ruivo, DVM, MSc, DACVP* Board-certified Comparative and Experimental Pathologist Co-coordinator, Laboratory Animal Pathology Residency and Fellowship Comparative Pathology Laboratory UC Davis School of Veterinary Medicine linkedin.com/in/pedro-ruivo-0b758667 <https://www.linkedin.com/in/pedro-ruivo-0b758667?lipi=urn%3Ali%3Apage%3Ad_f…> https://www.researchgate.net/profile/Pedro-Ruivo-5

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Davis-Thompson Foundation Newsletter: September 2024 issue
by Francisco Alejandro Uzal Sept. 1, 2024

Sept. 1, 2024

Dear colleagues Welcome to the September issue of the Davis-Thompson Foundation newsletter, skillfully prepared, as usual, by our awesome managing editors, Jeann Leal and Javier Asin. Thank you, Jeann and Javier! As you probably already noticed, the newsletter is becoming increasingly larger. This simply reflects the enormous amount of training activities that the Foundation offers every month, prepared and delivered by our incredibly generous volunteers. Thank you!!! Amongst the myriad training activities offered by the Foundation in the coming weeks/months, there are a few that I wish to highlight: If you are going to Nashville for the annual AAVLD meeting in October, do not forget to register for the DTF Pre-meeting Workshop on Dermatopathology with keynote speakers Dominique J. Wiener and Aline Rodrigues Hoffman. Do not miss this amazing opportunity to deepen your knowledge and network with experts in the field! And talking about AAVLD; in our ongoing commitment to fostering diversity, equity, and inclusion (DEI) within our field, we are excited to partner with the AAVLD Committee on DEI (AAVLDEI) to present an engaging workshop titled "Essential Skills for Civil Conversations". This event will take place on Saturday, October 12, from 6:30 to 8:00 PM. And remember that registration for the fully revamped Descriptive course, now Foundations of Pathology offered together with the annual meeting of ACVP, is open. Just a few spots are available; hurry up and register. If you are attending ACVP, consider also registering for our pre-meeting workshop "No guts-no glory", on tumors of the gastrointestinal tract, with a great list of speakers. In less than two weeks is the 3-day hands-on Racehorse Necropsy Workshop co-sponsored by the Horse Integrity and Safety Authority, for which only 2 seats remain available. If you registered for the waitlist, please check you emails (and spam folders) for messages from host.1(a)davisthompsonfoundation.org<mailto:host.1@davisthompsonfoundation.org>. Finally, as part of our ongoing efforts to offer scientific literature at very low cost, the Foundation just edited the book Intoxicaciones por plantas, micotoxinas y otras toxinas en rumiantes y équidos de Sudamérica, brilliantly written in Spanish by Drs Franklin Riet-Correa,Juan Francisco Micheloud, Mizael Machado, Fábio de Souza Mendonça, Ana Lucia Schild and Ricardo Antônio de Lemos. This is the first physical book in Spanish edited by the Foundation and we hope that there will be many more coming. The price is $ 40 plus postage; at 500 pages with 256 color illustrations, this is an incredible bargain! Also remember that we will be selling this, plus other books edited by the Foundation at AAVLD and ACVP (at discount prices), which will also save you shipping. Looking forward to seeing you in one of our upcoming seminars. Warm regards Francisco Uzal Chief Executive Officer Davis-Thompson Foundation Ph: 951 751 0027 E-mail: fauzal(a)ucdavis.edu<mailto:fauzal@ucdavis.edu> www.davisthompsonfoundation.org<https://www.davisthompsonfoundation.org/> [https://drive.google.com/uc?id=1oticUQZYjDPU-1vMA4wHKvLb2SScHV-J]

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DTF-LCPG #244 – Question Sheet
by claudio barros Sept. 1, 2024

Sept. 1, 2024

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DTF-LCPG # 243 – Answer Sheet
by claudio barros Sept. 1, 2024

Sept. 1, 2024

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2024 AAVLD Annual Meeting Davis-Thompson Pre-Meeting Workshop: Dermatopathology
by Bruce Williams Aug. 25, 2024

Aug. 25, 2024

[image: image.png] Going to Nashville for the 2024 AAVLD meeting? Don't forget to register for the 2024 AAVLD Annual Meeting DTF Pre-meeting Workshop on Dermatopathology with keynote speakers Dominique J. Wiener and Aline Rodrigues Hoffman. This in-person workshop will be held at the Gaylord Opryland Resort & Convention Center in Nashville, Tennessee. Don’t miss this amazing opportunity to deepen your knowledge and network with experts in the field! PROGRAM 8:00-8:10 Welcome/introductions. Francisco Uzal 8:10-9:00 Pattern analysis and species differences. Rodrigues Hoffmann and Dominique Wiener 9:00-10:00 Perivascular, lichenoid and interface diseases. Rodrigues Hoffmann 10:00-10:30 Refreshment break 10:30-11:15 Hyperkeratotic and hyperplastic diseases. Dominique Wiener 11:15-12:00 Pustular and vesiculobullous diseases. Dominique Wiener 12:00-13:30 Lunch (on your own) 13:30-14:15 Inflammatory follicular diseases. Rodrigues Hoffmann 14:15-15:00 Non-inflammatory follicular diseases. Dominique Wiener 15:00-15:30 Refreshment break 15:30-16:15 Histiocytic/nodular disease and panniculitis. Rodrigues Hoffmann 16:15-17:00 Vasculitis and dermal diseases. Dominique Wiener Registration: https://www.aavld.org/ 6.5h RACE pending approval -- Bruce Williams Chief Financial Officer Davis-Thompson Foundation 301 467-4024 bruce.williams(a)davisthompsonfoundation.org www.davisthompsonfoundation.org

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UMN CVM Anatomic Pathologist Position - Surgical Pathology
by Bruce Williams Aug. 24, 2024

Aug. 24, 2024

Summary of Duties and Responsibilities The College of Veterinary Medicine’s Department of Veterinary Population Medicine (VPM) at the University of Minnesota in St. Paul, Minnesota, invites applications for an outstanding contract (non-tenure) part-time (approximately 50% appointment) Veterinary Anatomic Pathologist faculty position at the rank of Assistant, Associate or Full Professor at the University of Minnesota Veterinary Diagnostic Laboratory (UMN VDL). The final rank and terms of appointment will depend on the qualifications and experience of the selected candidate consistent with Collegiate and University policies. Opportunities to increase effort appointment over time exist. The UMN VDL is an AAVLD-accredited, full-service laboratory that serves veterinarians, scientists, educators, companion animal owners, and the livestock and poultry industry by identifying and monitoring emerging diseases and developing new diagnostic methods. The UMN VDL is also the official laboratory for the Minnesota Board of Animal Health (MBAH). The primary responsibility of this position will be to provide surgical pathology service and resident training. The role will provide diagnostic pathology support focusing on biopsy cases routinely submitted to the UMN VDL, and delivery of comprehensive diagnostic case information in a concise and well-organized manner to the College of Veterinary Medicine Veterinary Medical Center, practicing veterinarians, and other animal health professionals. Responsibilities will include review of glass and/or digitized histopathology slides (histochemical and immunohistochemical stains) and generation of reports including diagnoses, microscopic descriptions, photomicrographs, and pertinent comments. Other key responsibilities include the incorporation of ancillary test results and case information and consultation with both referring veterinarians and faculty veterinarians in the University of Minnesota College of Veterinary Medicine. The person in this position will be actively involved in surgical pathology training of anatomic pathology residents and other specialty residencies. While the caseload is composed primarily of companion animal biopsy cases, it is expected that the candidate may also receive cases from other species, including food animal, avian, or wildlife submissions. The successful candidate must have a collegial, collaborative attitude and willingness to participate in departmental programs and committees. The candidate will join an interdisciplinary team of veterinarians teachers and researchers. The candidate will demonstrate commitment to delivering exceptional diagnostic service, dedication to all levels of education, and contribute to the national prominence of the UMN VDL, VPM Department, and the University of Minnesota. The University of Minnesota especially seeks candidates who are interested in contributing to the diversity and excellence of the academic community through their research, teaching, and outreach. Required Minimum Qualifications: ● DVM or equivalent degree. ● Board certification by the American College of Veterinary Pathologists (ACVP) or European College of Veterinary Pathologists (ECVP) ● At least two years of experience in anatomic pathology diagnostics including biopsies ● Experience and ability to work with culturally diverse groups of people and excellent communication skills. Preferred Qualifications: ● MS or PhD or equivalent degree in Veterinary Pathology or closely related veterinary fields. ● Clinical experience of small animal medicine including preventive care, and elective soft tissue procedures. ● Experience in teaching veterinary students and/or veterinary pathology residents, graduate students, and other trainees. ● Pathology training and working experience in a veterinary diagnostic laboratory. Salary: Commensurate with experience and qualifications. The University of Minnesota provides benefits commensurate with effort. Begin: The position is available immediately. The starting date can be negotiated with the selected candidate. Location: This position will be located in the College of Veterinary Medicine in the St. Paul Campus of the University of Minnesota, in St. Paul, MN. Application Qualified applicants should apply online at https://hr.myu.umn.edu/jobs/ext/364206 (Job ID: 364206) and include a letter of intent, a diversity statement, curriculum vitae, and a list of three references (with contact information) knowledgeable about the candidate's diagnostic service, research, teaching, and outreach skills. Applicant’s diversity statement should address what contributions exemplify your awareness and sensitivity toward promoting a diverse and inclusive environment. “What have you learned working with diverse populations?” Review of applications will begin September 15, 2024, and continue until the position is filled. *Questions regarding this position may be sent to the search committee administrator Ms. Anna Jones at bystr005(a)umn.edu <bystr005(a)umn.edu>. * The University of Minnesota is an equal opportunity educator and employer.

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The Ohio State University position announcement: Comparative/Lab Animal Pathologist, clinical track
by Jey Koehler Aug. 22, 2024

Aug. 22, 2024

The Department of Veterinary Biosciences (VBS) in the College of Veterinary Medicine (CVM), in conjunction with the James Comprehensive Cancer Center (OSUCCC) at The Ohio State University (OSU) is seeking applicants for a clinical-track faculty position at the Assistant or Associate Professor level in Comparative/Laboratory Animal Pathology. For more information about the position and how to apply, please see the attached position announcement. Please do not reply to this email…we are just the messengers! 😊 Jey Koehler, DVM, PhD, Dipl. ACVP Professor and Tyler & Frances Young Endowed Chair in Pathology Auburn University College of Veterinary Medicine President, Davis-Thompson Foundation www.davisthompsonfoundation.org<http://www.davisthompsonfoundation.org/>

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DTF-LCPG # 243 – Question Sheet
by claudio barros Aug. 15, 2024

Aug. 15, 2024

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DTF-LCPG # 242 – Answer Sheet
by claudio barros Aug. 15, 2024

Aug. 15, 2024

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Fellowship Program in Musculoskeletal Pathology of Racehorses
by Francisco Alejandro Uzal Aug. 9, 2024

Aug. 9, 2024

Dear colleagues Attached is a great and unique training opportunity for those interested in the musculoskeletal system of racehorses. The position is based in the San Bernardino lab of CAHFS, UCDavis, California. Please do not hesitate to contact me if you have any questions. Kind regards Francisco Uzal, DVM, MSc, PhD, Dipl. ACVP Chief Executive Officer Davis-Thompson Foundation Ph: 951 751 0027 E-mail: fauzal(a)ucdavis.edu<mailto:fauzal@ucdavis.edu> www.davisthompsonfoundation.org<https://www.davisthompsonfoundation.org/> [https://drive.google.com/uc?id=1oticUQZYjDPU-1vMA4wHKvLb2SScHV-J]

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