It's not a Foundation publication, but the authors have all been great supporters, and some officers of the Foundation, so we are happy to give this one a boost! (Just don't expect Foundation pricing from Elsevier!)
Haschek and Rousseaux's Handbook of Toxicologic Pathology,
Volume 1: Principles and Practice of Toxicologic Pathology
4th Edition - October 20, 2021
Editors: Wanda Haschek, Colin Rousseaux, Matthew Wallig, Brad Bolon
Hardcover ISBN: 9780128210444
eBook ISBN: 9780128218297
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology
The Handbook of Toxicologic Patholog has been extensively updated to continue its comprehensive and timely coverage. The 4th edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology has been expanded to 4 separate volumes due to unrelenting explosion of information in this field requiring new and updated chapters These volumes are being published separately.
Volume 1, “Principles and the Practice of Toxicologic Pathology,” is now available and discussed in detail below. Volume 2, currently in press, encompasses “Toxicologic Pathology in Safety Assessment” and “Environmental Toxicologic Pathology”. These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4, currently in preparation, provide deep and broad treatment of “Target Organ Toxicity”, emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity.
Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 1 of the Fourth Edition covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Completely revised with a number of new chapters, Volume 1 of the Handbook of Toxicologic Pathology is an essential part of the authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.
Key Features
Provides new chapters on digital pathology, juvenile pathology, animal models, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology
Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
Features full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations
Audience
Scientists, including pathologists, toxicologists and graduate students, in academia, industry and government. Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories; regulatory agencies and universities
Table of Contents
Chapter 1. Toxicologic Pathology: An Introduction
Part 1. Principles of Toxicologic Pathology
Chapter 2. Biochemical and Molecular Basis of Toxicity
Chapter 3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective
Chapter 4. Biotherapeutics ADME and PK/PD Principles
Chapter 5. Principles of Pharmacodynamics and Toxicodynamics
Chapter 6. Morphologic Manifestations of Toxic Cell Injury
Chapter 7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity
Chapter 8. Carcinogenesis: Mechanisms and Evaluation
Part 2. Methods in Toxicologic Pathology
Chapter 9. Basic Approaches in Anatomic Toxicologic Pathology
Chapter 10. Clinical Pathology in Nonclinical Toxicity Testing
Chapter 11. Special Techniques in Toxicologic Pathology
Chapter 12. Digital Pathology and Tissue Image Analysis
Chapter 13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models
Chapter 14. Biomarkers: Discovery, Qualification, and Application
Chapter 15. Toxicogenomics: A Primer for Toxicologic Pathologists
Chapter 16. Experimental Design and Statistical Analysis for Toxicologic Pathologists
Part 3. Animal and Alternative Models in Toxicologic Research
Chapter 17. Animal Models in Toxicologic Research: Rodents
Chapter 18. Animal Models in Toxicologic Research: Rabbit
Chapter 19. Animal Models in Toxicologic Research: Dog
Chapter 20. Animal Models in Toxicologic Research: Pig
Chapter 21. Animal Models in Toxicologic Research: Nonhuman Primate
Chapter 22. Animal Models in Toxicologic Research: Nonmammalian
Chapter 23. Genetically Engineered Animal Models in Toxicologic Research
Chapter 24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Nontraditional In Vivo Approaches
Part 4. Practice of Toxicologic Pathology
Chapter 25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology
Chapter 26. Pathology Peer Review
Chapter 27. Pathology and GLPs, Quality Control, and Quality Assurance
Chapter 28. Practices to Optimize Generation, Interpretation, and Reporting of Pathology Data from Toxicity Studies
Chapter 29. Issues in Laboratory Animal Science That Impact Toxicologic Pathology
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